Bioactivity | [(Cys(Bzl)84,Glu(OBzl)85)]CD4 (81-92) is a selective inhibitor of HIV-1. [(Cys(Bzl)84,Glu(OBzl)85)]CD4 (81-92) inhibits viral infection and cell fusion by blocking the interaction between HIV-1 and CD4 molecules. [(Cys(Bzl)84,Glu(OBzl)85)]CD4 (81-92) can completely inhibit fusion formation at a concentration of 25 μM[1]. |
CAS | 124699-95-2 |
Sequence | Thr-Tyr-Ile-{Cys(Bzl)}-{Glu(OBzl)}-Val-Glu-Asp-Gln-Lys-Glu-Glu |
Shortening | TYI-{Cys(Bzl)}-{Glu(OBzl)}-VEDQKEE |
Formula | C76H108N14O26S |
Molar Mass | 1665.81 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Nara PL, et al. CD4 antigen-based antireceptor peptides inhibit infectivity of human immunodeficiency virus in vitro at multiple stages of the viral life cycle. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7139-43. |